The Molecular Basis of T Cell Receptor Cross-Reactivity Between MHC and MR1

Allelic variation alters expression and antigen presentation of MR1 allomorphs

AG Nelson, V Letoga, CZQ Lee, C Samer, S Li, LJ Meehan, HEG McWilliam, NA Gherardin, A Abendroth, JA Villadangos, B Slobedman, AJ Corbett, J McCluskey, J Rossjohn, Z Chen, MNT Souter, W Awad

2026-06-01

The major histocompatibility complex (MHC) class I-related protein 1 (MR1) presents vitamin B-derived metabolites to mucosal-assoc..

Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions

W Awad, MR Abdelaal, V Letoga, J McCluskey, J Rossjohn

2025-05-01

The major histocompatibility complex class-I related protein, MR1, is an evolutionarily conserved antigen presenting molecule that..

MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells

MP McInerney, W Awad, MNT Souter, Y Kang, CJH Wang, KCY Poa, MR Abdelaal, NH Le, CM Shepherd, C McNeice, LJ Meehan, AG Nelson, JM Raynes, JYW Mak, J McCluskey, Z Chen, CS Ang, DP Fairlie, JL Nours, PT Illing

2024-12-03

The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-a..