The Molecular Basis of T Cell Receptor Cross-Reactivity Between MHC and MR1

Allelic variation alters expression and antigen presentation of MR1 allomorphs

Adam G Nelson, Victoria Letoga, Clarice ZQ Lee, Carolyn Samer, Songyi Li, Lucy J Meehan, Hamish EG McWilliam, Nicholas A Gherardin, Allison Abendroth, Jose A Villadangos, Barry Slobedman, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Zhenjun Chen, Michael NT Souter, Wael Awad

2026-04-01

The major histocompatibility complex (MHC) class I-related protein 1 (MR1) presents vitamin B- derived metabolites to mucosal-asso..

Molecular Insights Into MR1-Mediated T Cell Immunity: Lessons Learned and Unanswered Questions

W Awad, MR Abdelaal, V Letoga, J McCluskey, J Rossjohn

2025-05-01

The major histocompatibility complex class-I related protein, MR1, is an evolutionarily conserved antigen presenting molecule that..

MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells

MP McInerney, W Awad, MNT Souter, Y Kang, CJH Wang, KCY Poa, MR Abdelaal, NH Le, CM Shepherd, C McNeice, LJ Meehan, AG Nelson, JM Raynes, JYW Mak, J McCluskey, Z Chen, CS Ang, DP Fairlie, JL Nours, PT Illing

2024-12-03

The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-a..